The Journal of the American Jeart Association Augmentation of Vasoactive Substances by Tetraethylammonium Chloride
نویسنده
چکیده
This investigation attempts to demonstrate the mechanism by which substances that block autonomic ganglionic transmission increase the pressor and depressor activities of a variety of (irugs. Short-lived hypertension and a high degree of vascular responsiveness is induced by combining cord destruction, inactivation of the carotid sinus mechanism and nephreetomn. The increased responsiveness is found to be due to removal of the compensatory nervous mechanisms which tend to oppose changes in blood pressure. It may be reduced or abolished by hepatectomy, severe hypotension and shock.
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